24-Chromosome Genetic Testing for Embryos Using NGS (Next-Generation Sequencing)
NGS Technology in Embryo Testing
Next-Generation Sequencing (NGS) is an advanced genetic sequencing technique that enables a comprehensive and precise analysis of all 24 chromosomes. This allows for a more detailed identification of genetic abnormalities compared to traditional methods such as Fluorescence In Situ Hybridization (FISH) or Polymerase Chain Reaction (PCR).
Importance of 24-Chromosome Testing for Embryos Using NGS
Comprehensive genetic Testing aims to:
- Enhance the chances of a successful pregnancy by selecting genetically healthy embryos.
- Reduce the risk of miscarriage caused by chromosomal abnormalities.
- Detect genetic disorders such as Down syndrome (Trisomy 21), Edwards syndrome, and Patau syndrome.
- Improve the success rate of in vitro fertilization (IVF) by transferring genetically normal embryos.
- Prevent hereditary diseases that could be passed on to the offspring.
- Assist in gender selection for couples with medical or genetic reasons requiring such a choice.
How Is Genetic Testing for Embryos Performed?
Genetic testing using NGS follows these steps:
- Embryo Biopsy: A sample of cells is extracted from the embryo at the blastocyst stage (Day 5 or Day 6 of development).
- Genetic Material Analysis: The DNA is analyzed in the laboratory using NGS technology.
- Selection of Healthy Embryos: Only embryos without chromosomal abnormalities are chosen for transfer into the mother’s uterus.
Who Can Benefit from Embryo Genetic Testing?
This test is recommended in the following cases:
- Couples with a family history of genetic disorders.
- Women aged 35 and above, as the risk of chromosomal abnormalities increases with age.
- Couples with a history of recurrent miscarriages or repeated IVF failures.
- Couples experiencing unexplained infertility.
- Couples who wish to select the gender of their baby for medical or family-related reasons.
